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A similar situation occurred is the study of HIV. For many years, the afflicted were studied. This was necessary to contain spread and discover treatments and cures. However, after some time and with genetic testing which was unavailable at the beginning of the HIV pandemic, a different approach developed. Researchers began studying those patients who were exposed to HIV and appeared to be immune. These patients had numerous opportunities to be infected yet never developed the disease. Great breakthroughs have been made by studying the exceptions rather than the rules. There is evidence of genetic immunity with HIV infection. Researchers are working on whether this genetic variant was favored by smallpox or the plague. In other words, because this variant protected people from dying hundreds or thousands of years ago, they survived instead of dying. They were the ones able to live and pass on this protective gene,

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